کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3256966 1207381 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Eosinophil recruitment to nasal nerves after allergen challenge in allergic rhinitis
چکیده انگلیسی

In allergen challenged animal models, eosinophils localize to airway nerves leading to vagally-mediated hyperreactivity. We hypothesized that in allergic rhinitis eosinophils recruited to nasal nerves resulted in neural hyperreactivity. Patients with persistent allergic rhinitis (n = 12), seasonal allergic rhinitis (n = 7) and controls (n = 10) were studied. Inferior nasal turbinate biopsies were obtained before, 8 and 48 h after allergen challenge. Eight hours after allergen challenge eosinophils localized to nerves in both rhinitis groups; this was sustained through 48 h. Bradykinin challenge, with secretion collection on the contralateral side, was performed to demonstrate nasal nerve reflexes. Twenty four hours after allergen challenge, bradykinin induced a significant increase in secretions, indicating nasal hyperreactivity. Histological studies showed that nasal nerves expressed both vascular cell adhesion molecule-1 (VCAM-1) and chemokine (C-C motif) ligand 26 (CCL-26). Hence, after allergen challenge eosinophils are recruited and retained at nerves and so may be a mechanism for neural hyperreactivity.


► Eosinophils are prominent in the nasal tissue of patients with rhinitis.
► Eosinophils localize to nasal nerves in allergen challenged patients with rhinitis.
► Interaction occurs in association with the induction of nasal nerve hyperreactivity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 147, Issue 1, April 2013, Pages 50–57
نویسندگان
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