کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257020 1207386 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Innate immune processes in lupus erythematosus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Innate immune processes in lupus erythematosus
چکیده انگلیسی

The innate immune system is involved in the pathogenesis of systemic autoimmune diseases such as systemic lupus erythematosus (SLE) or dermatomyositis. The important role of complement factors of the classical pathway and of Toll like receptors (TLRs) is well established, based on genetic and clinical evidence. Immune complexes activate tumor necrosis factor (TNF) in myeloid cells and interferon-α (IFNα) in plasmacytoid dendritic cells. The latter initiates a positive feedback loop that drives autoimmunity. More recently, mutations in genes encoding intracellular enzymes involved in RNA and DNA handling, which likewise lead to increased IFNα, have been found to cause familial chilblain lupus and to be associated with SLE. Within the immunological disease continuum, these disorders can be placed between autoinflammation and autoimmunity, and we would propose the term autoadjuvant for this group, since the activation of the innate immune system in these diseases appears to lower the threshold for (auto)immune reactions.


► Mechanisms of innate immunity are intimately involved in SLE pathophysiology.
► Classical pathway complement component deficiences are highly associated with SLE.
► Toll like receptors 7 and 9, blocked by antimalarials, lead to IFNα, TNF production.
► Genes necessary for RNA/DNA handling are found mutated in lupus patients.
► IFNα, which appears to function as an adjuvant, probably links these findings.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 147, Issue 3, June 2013, Pages 216–222
نویسندگان
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