کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257237 1589431 2011 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thymic microenvironment reconstitution after postnatal human thymus transplantation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Thymic microenvironment reconstitution after postnatal human thymus transplantation
چکیده انگلیسی

A functional thymus develops after cultured thymus tissue is transplanted into subjects with complete DiGeorge anomaly. To gain insight into how the process occurs, 7 post-transplantation thymus biopsy tissues were evaluated. In 5 of 7 biopsies, the thymus appeared to be predominantly cortex with thymocytes expressing cortical markers. Unexpectedly, the epithelium expressed both cortical [cortical dendritic reticulum antigen 2 (CDR2)] and medullary [cytokeratin (CK) 14] markers. Early medullary development was suggested by epithelial cell adhesion molecule (EpCAM) reactivity in small areas of biopsies. Two other biopsies had distinct mature cortex and medulla with normal restriction of CK14 to the medulla and subcapsular cortex, and of CDR2 to cortex. These data are consistent with a model in which thymic epithelium contains CK14+ “progenitor epithelial cells”. After transplantation these cells proliferate as CK14+CDR2+ thymic epithelial cells that are associated with cortical thymocytes. Later these cells differentiate into distinct cortical and medullary epithelia.

Research highlights
► Thymic allograft biopsies were evaluated after thymus transplantation.
► Thymic epithelial cells unexpectedly express both cortical and medullary markers.
► Thymic tissue may regenerate from precursor epithelial cells.
► Foxn1 is highly expressed in thymus epithelial cells in the allograft biopsies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 140, Issue 3, September 2011, Pages 244–259
نویسندگان
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