کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257392 1207412 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Study of thymic size and function in children and adolescents with treatment refractory systemic sclerosis eligible for immunoablative therapy
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Study of thymic size and function in children and adolescents with treatment refractory systemic sclerosis eligible for immunoablative therapy
چکیده انگلیسی

Following hematopoietic stem cell transplantation (HSCT), thymic reconstitution of peripheral T lymphocytes is essential to avoid a chronically immunodeficient state and disease recurrence. The purpose of this study was to determine if children and adolescents with treatment refractory SSc, awaiting HSCT, have sufficient thymic function to reconstitute T lymphocyte function after transplantation.Thirteen children with systemic scleroderma were enrolled and assessed by physical exam, chest MRI, measurement of autoantibodies, B and T cell immuno-phenotyping, and quantization of T cell receptor rearrangement excision circles (TREC) as a marker of thymopoiesis.MRI detected thymic tissue in 9/13 children. TREC levels were detectable in all but one child but were significantly reduced (p < 0.001) when compared to a control population. SSc patients also had a reduced percentage of naïve (CD45RA + CD31+) CD4+ T lymphocytes, further indicating diminished thymopoiesis.Our data suggest that thymic function in children with SSc might be insufficient for an adequate immunoreconstitution following transplantation in some patients. A thorough evaluation of immune and thymic functions to identify those patients prior to HSCT is recommended.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 133, Issue 3, December 2009, Pages 295–302
نویسندگان
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