کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257419 1589432 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effect of aging on T-regulatory cell frequency in HIV infection
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The effect of aging on T-regulatory cell frequency in HIV infection
چکیده انگلیسی

T-regulatory cell (T-reg) frequency is increased in HIV infection and with aging. We evaluated the effect of age on total, memory and naïve T-reg percentages in untreated HIV infection. Older HIV+ subjects had a total T-reg percent that is 2.8% (p = 0.02) higher than among younger HIV+, older HIV− and younger HIV− subjects. In HIV+ subjects, the total T-reg percentage is inversely correlated with the lymphocyte proliferative responses to tetanus (r = − 0.45, p = 0.002) and Candida (r = − 0.43, p = 0.003) antigens. Similar correlations were seen between memory T-reg percentages and the lymphocyte proliferative response to tetanus and Candida in HIV+ subjects. T-reg percentages did not correlate consistently with markers of immune activation. T-reg percentages are increased in the older HIV+ population and may play a role in the accelerated disease progression seen in older HIV-infected persons.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 130, Issue 3, March 2009, Pages 298–303
نویسندگان
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