کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3257872 1207430 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Mannose binding lectin gene polymorphisms and associated auto-immune diseases in type 1 diabetes Brazilian patients
چکیده انگلیسی

In our study we investigated the possible role of MBL2 functional single nucleotide polymorphisms (SNPs) in the augmented susceptibility to develop other autoimmune diseases in presence of type 1 diabetes (T1D) in a group of Brazilian patients. Patients were stratified for the presence of autoimmune diseases known to be associated with T1D, such as autoimmune thyroid disease (AITD) and celiac disease (CD), and compared with healthy controls (HC).Our findings suggest that MBL2 functional SNPs are more closely related to AITD than to T1D, being MBL2 SNPs frequencies in T1D patients not affected by AITD comparable to the HC ones, while significantly different between AITD patients and patients not affected by the disease.Thus, the association between MBL2 polymorphisms and T1D that we previously reported, seems to result from the stronger association of MBL2 SNPs with another autoimmune disease, the AITD, frequently associated with T1D.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 131, Issue 2, May 2009, Pages 254–259
نویسندگان
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