کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3258355 | 1207450 | 2007 | 8 صفحه PDF | دانلود رایگان |
Proinflammatory cytokines as well as CD4+ T cells play critical roles in the pathogenesis of rheumatoid arthritis (RA). Recently, an increase of CD57+ or CD28−CD4+ T cells was demonstrated in RA, although the mechanism of the increase of these T cells is unclear. In this study, we first examined the relationship between CD57+CD4+ T cells and CD28−CD4+ T cells and found CD57+CD28−CD4+ T cells, but neither CD57+CD28+ nor CD57−CD28+ cells, expanded in the peripheral blood of active RA. In vitro experiments revealed that CD57+CD28−CD4+ T cells selectively expanded in response to IL-15. Furthermore IL-15-stimulated CD57+CD28−CD4+ T cells induced TNF-α production from monocytes. These results suggest that CD57+CD28−CD4+ T cells are involved in the pathogenesis of RA by responding to IL-15.
Journal: Clinical Immunology - Volume 124, Issue 3, September 2007, Pages 328–335