کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3258425 | 1207454 | 2007 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum surfactant protein D is correlated to development of dementia and augmented mortality
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Serum surfactant protein D is correlated to development of dementia and augmented mortality Serum surfactant protein D is correlated to development of dementia and augmented mortality](/preview/png/3258425.png)
چکیده انگلیسی
Development of dementia, including Alzheimer's disease (AD), is associated with lipid dysregulation and inflammation. As the host defense lectin surfactant protein D (SP-D) has multiple effects in lipid homeostasis and inflammation, the correlation between SP-D concentrations and development of dementia was investigated. A total of 418 non-demented persons were included in the study and cognitively re-examined after 3Â years, while survival was followed for 11Â years. Serum SP-D concentrations were measured at baseline. Logistic regression analysis controlling for age, gender, smoking status, and CRP showed that Odds Ratio for developing dementia was 2.62 (1.12-6.15) with an SP-D concentration in the highest quartile compared to the other quartiles. The risk of AD was 2.55 (0.95-6.90). Cox regression controlling for the same variables showed that hazard ratio of death was 1.43 (1.06-1.92) in the highest quartile. SP-D concentration thus correlates to development of dementia as well as to augmented mortality.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Immunology - Volume 123, Issue 3, June 2007, Pages 333-337
Journal: Clinical Immunology - Volume 123, Issue 3, June 2007, Pages 333-337
نویسندگان
Mads Nybo, Kjeld Andersen, Grith L. Sorensen, Anette Lolk, Per Kragh-Sorensen, Uffe Holmskov,