کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3270479 | 1208241 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bone Density Is Directly Associated With Glomerular Filtration and Metabolic Acidosis but Do Not Predict Fragility Fractures in Men With Moderate Chronic Kidney Disease
ترجمه فارسی عنوان
تراکم استخوانی به طور مستقیم با فیلتراسیون گلومرولی و اسیدوز متابولیک مرتبط است، اما شکستگی های شکننده را پیش بینی نمی کند در مردان مبتلا به بیماری مزمن کلیوی
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی
Hyperparathyroidism, vitamin D deficiency, increased fibroblast growth factor-23 (FGF-23), and metabolic acidosis promote bone fragility in chronic kidney disease (CKD). Although useful in predicting fracture risk in the general population, the role of dual-energy X-ray absorptiometry (DXA) in CKD remains uncertain. This cross-sectional study included 51 men aged 50-75 yr with moderate CKD. The stage 4 CKD patients had higher levels of parathyroid hormone (p < 0.001), FGF-23 (p = 0.029), and lowest 25-hydroxyvitamin D (p = 0.016), bicarbonate (p < 0.001), total femur (p = 0.003), and femoral neck (p = 0.011) T-scores compared with stage 3 CKD patients. Total femur and femoral neck T-scores were directly correlated with serum bicarbonate (p = 0.003, r = 0.447 and p = 0.005, r = 0.427, respectively) and estimated glomerular filtration rate (p = 0.024, r = 0.325 and p = 0.003, r = 0.313, respectively) but were not significantly associated with parathyroid hormone, 25-hydroxyvitamin D, or FGF-23. Only 3.9% of the participants had osteoporosis on DXA scan, whereas 31.4% reported a low-impact fracture. Our data point to a pivotal role of metabolic acidosis for bone impairment and to the inadequacy of DXA to evaluate bone fragility in CKD patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Densitometry - Volume 19, Issue 2, April 2016, Pages 146-153
Journal: Journal of Clinical Densitometry - Volume 19, Issue 2, April 2016, Pages 146-153
نویسندگان
Guilherme Alcantara Cunha Lima, Francisco de Paula Paranhos-Neto, Luciana Colonese Silva, Laura Maria Carvalho de Mendonça, Alvimar Gonçalves Delgado, Maurilo Jr., Carlos Perez Gomes, Maria Lucia Fleiuss Farias,