کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328478 | 1212311 | 2012 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Hepcydyna w patogenezie niedokrwistoÅci w przebiegu szpiczaka plazmocytowego
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Hepcydyna w patogenezie niedokrwistoÅci w przebiegu szpiczaka plazmocytowego Hepcydyna w patogenezie niedokrwistoÅci w przebiegu szpiczaka plazmocytowego](/preview/png/3328478.png)
چکیده انگلیسی
Hepcidin is a peptide, isolated in the nineties of the twentieth century, synthesized mainly in the liver. This antibacterial and antifungal protein has also an impact on iron homeostasis in human organism. Hepcidin is a regulator of iron releasing from enterocytes, hepatocytes and macrophages to blood circulation. Hepcidin binds to ferroportin on cell surface and hepcidin-ferroportin complex is internalized and degraded intracellularly. The effect of this process is reduction of iron releasing from cells. Overproduction of hepcidin leads to iron retention in macrophages and reduced concentration of this element in the circulation. This state is observed in patients presenting anaemia of chronic disease (ACD). The example of disease, where anaemia is an important symptom, is multiple myeloma (MM). The study conducted so far indicates that hepcidin may play a great role in the pathogenesis of anaemia in MM, as it is a protein regulating iron homeostasis in human organism. It was revealed, that in patients with multiple myeloma, hepcidin concentration was raised, which may be related with factors stimulating hepcidin production, such as interleukin-6 and bone morphogenetic protein 2.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 43, Issue 4, OctoberâDecember 2012, Pages 326-330
Journal: Acta Haematologica Polonica - Volume 43, Issue 4, OctoberâDecember 2012, Pages 326-330
نویسندگان
Michalina Krydel,