کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3328490 | 1212312 | 2012 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Leki immunomodulujÄ
ce oraz inhibitory proteasomów w leczeniu chorych na szpiczaka plazmocytowego z niewydolnoÅciÄ
nerek
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Leki immunomodulujÄ
ce oraz inhibitory proteasomów w leczeniu chorych na szpiczaka plazmocytowego z niewydolnoÅciÄ
nerek Leki immunomodulujÄ
ce oraz inhibitory proteasomów w leczeniu chorych na szpiczaka plazmocytowego z niewydolnoÅciÄ
nerek](/preview/png/3328490.png)
چکیده انگلیسی
while renal impairment is present in 50% of multiple myeloma patients at some point in their disease course, it is associated with higher tumor burden, more aggressive disease, diminished quality of life, development of complications and increased mortality. Patients presenting severe renal impairment represent a greater therapeutic challenge and generally have poorer outcome. Bortezomib, thalidomide, and lenalidomide have substantially improved survival of MM patients including patients with renal insufficiency. we review efficacy and safety of these agents in patients with renal impairment. Bortezomib can be administered at the full approved dose and schedule in renally impaired patients; similarly, no dose reductions are required with thalidomide. Lenalidomide pharmacokinetics is affected due to its renal route of excretion; dose adjustments are recommended for moderate/severe impairment. Substantial evidence has emerged demonstrating these novel agents improve outcomes of patients with renal impairment, including impairment reversal.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Acta Haematologica Polonica - Volume 43, Issue 2, Part B, SeptemberâDecember 2012, Pages 173-186
Journal: Acta Haematologica Polonica - Volume 43, Issue 2, Part B, SeptemberâDecember 2012, Pages 173-186
نویسندگان
Grzegorz CharliÅski, Grzegorz Ostrowski, Elżbieta Wiater,