کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328511 1590710 2016 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Infertility risk and teratogenicity of molecularly targeted anticancer therapy: A challenging issue
ترجمه فارسی عنوان
خطر ناباروری و تراتوژنیک درمان ضد سرطان هدفمند مولکولی: یک مسئله به چالش کشیدن است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

The growing population of young cancer survivors and a trend toward postponing pregnancy until later in life are shifting areas of focus toward understanding treatment induced sequelae, particularly the effects of cancer and/or treatment on fertility. Whereas the fertility risk of cytotoxic agents for both men and women is well-recognized, the fertility risks and teratogenic potential associated with molecular targeted therapies are not established. We summarize available preclinical and clinical data on the impact of new molecular targeted agents on fertility in both sexes, and their potential teratogenic effects, providing recommendations for clinicians, where possible. Agents were categorized by class and the potential relevance of their target signaling pathways to gonadal maturation discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 107, November 2016, Pages 1–13
نویسندگان
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