کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
332852 545772 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—a postmortem study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Evidence for oxidative stress in the frontal cortex in patients with recurrent depressive disorder—a postmortem study
چکیده انگلیسی

Prefrontal cortical (PFC) and hippocampal (HI) volume reductions have been consistently found in patients with recurrent depressive disorder (DD). Here we examine the possibility that oxidative stress, widely implicated in neuronal cell damage, may contribute to these brain structural changes. We compared manganese (Mn) and copper/zinc (Cu/Zn) superoxide dismutase (SOD) coenzyme concentrations in postmortem PFC and hippocampal brain tissue from 7 patients with DD and 7 neuropsychiatrically healthy controls using sandwich-type enzyme-linked immunosorbent assay (ELISA) technique. The concentration of Cu/Zn-SOD was significantly increased in the PFC but not in the hippocampus of patients. There was no significant change in Mn-SOD enzyme concentration in either region. Our findings contribute to the growing body of evidence implicating oxidative stress in the pathophysiology of depressive disorder.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research - Volume 151, Issues 1–2, 30 May 2007, Pages 145–150
نویسندگان
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