کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3328681 1212332 2014 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Phosphofructokinase: A mediator of glycolytic flux in cancer progression
ترجمه فارسی عنوان
فسفوفروتکتیناز: یک واسطه شار گلیکولیتیک در پیشرفت سرطان
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی

In view of the current limitations of cancer chemotherapy, there has been resurgent interest in re-visiting glycolysis to determine whether tumors could be killed by energy deprivation rather than solely by strategies to inhibit proliferation. Cancer cells exhibit a uniquely high rate of glucose utilization, converting it into lactate whose export subsequently creates an acidic extracellular environment that is thought to promote invasion and metastasis, in preference to its complete oxidation even in the presence of adequate oxygen supply. Reductive analysis of each step of glycolysis shows that, of the three rate limiting enzymes of the pathway, isoforms of phosphofructokinase may afford the greatest opportunity as targets to deprive cancer cells from essential energy and substrates for macromolecular synthesis for proliferation while allowing normal cells to survive. Strategies discussed include restricting the substrate for this enzyme. While prospects for monotherapy with glycolytic inhibitors are poor, combination therapy may be productive.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 92, Issue 3, December 2014, Pages 312–321
نویسندگان
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