کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3329003 1212369 2012 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer
چکیده انگلیسی

Despite major advances in cancer therapeutics, the prognosis for lung cancer patients is still poor and the median survival for patients presenting with advanced non-small cell lung cancer (NSCLC) is only 8–10 months. Angiogenesis is an important biological process and a relatively early event during lung cancer pathogenesis. Anti-angiogenic agents are used in treating patients with NSCLC, and their molecular biomarkers are also being assessed to predict response. A better understanding of the biology of angiogenesis in NSCLC may reveal new targets for treating this malignancy. In this article, we review the expression and prognostic impact of the angiogenic growth factors, vascular endothelial growth factor and basic fibroblast growth factor, in NSCLC.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 84, Issue 2, November 2012, Pages 149–160
نویسندگان
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