کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3329068 1212374 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Primary plasma cell leukemia in the era of new drugs: Has something changed?
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
پیش نمایش صفحه اول مقاله
Primary plasma cell leukemia in the era of new drugs: Has something changed?
چکیده انگلیسی

Primary plasma cell leukemia (PPCL) is a rare and aggressive variant of multiple myeloma. This disease is associated with a very poor prognosis, and unfortunately it has not significantly improved during the last three decades. Autologous stem cell transplantation is generally recommended in eligible patients, but survival in transplanted PPCL patients is significantly lower than that of multiple myeloma. Recent preliminary data indicate that new drugs, in particular lenalidomide and bortezomib, could significantly improve the clinical outcome of PPCL, increasing response rate and duration, as well as survival. In this review we report an updated literature analysis about the current therapeutic scenario of PPCL, with a particular focus on the use of novel agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Critical Reviews in Oncology/Hematology - Volume 82, Issue 2, May 2012, Pages 141–149
نویسندگان
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