کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3333252 1213301 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Traitement de l'aplasie médullaire idiopathique en 2015
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Traitement de l'aplasie médullaire idiopathique en 2015
چکیده انگلیسی
Idiopathic aplastic anemia is a rare hemopoietic stem cell disorder that results in pancytopenia and hypocellular bone marrow. Allogeneic bone marrow transplantation from an HLA-identical sibling donor is the choice treatment for young patients (40 years of age or less) and leads to long-term survival in the majority of patients (> 90 %). For patients without a sibling donor, transplantation from a well-matched unrelated donor can be considered after failure of a previous course of immunosuppressive therapy. For patients who do not have a matched unrelated donor or who are not eligible for transplantation, a new course of immunosuppression can be discussed, as well as other treatment possibilities including androgens or eltrombopag. Alternative allogeneic stem cell transplantation (cord blood, haplo-identical transplantation or from mismatched donor), as well as upfront matched unrelated donor transplantation are still experimental and should not be completed outside clinical trials. This review illustrates an educational session on aplastic anemia, which took place at the last French society meeting in Paris and summarizes the treatment algorithm in patients with idiopathic aplastic anemia in 2015.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue d'Oncologie Hématologie Pédiatrique - Volume 3, Issue 3, September 2015, Pages 139-144
نویسندگان
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