کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3335202 | 1213524 | 2013 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia Apheresis-inducible cytokine pattern change in children with homozygous familial hypercholesterolemia](/preview/png/3335202.png)
Familial hypercholesterolemia is a genetic disorder that leads to severe atherosclerosis related cardiovascular complications in young adults. Extracorporeal elimination is a method of LDL-lowering procedures effective in patients with homozygous or severe heterozygous FH utilized in cases. The recruitment of leucocytes into the arterial intima is dependent on a cascade of events mediated through a diverse family of adhesion molecules. Several pro-inflammatory adhesion molecules are cleared by various lipid apheresis methods. This study showed that, LDL-apheresis led to several changes in circulating inflammatory factors which induced antiinflammatory and antiatherogenic changes in the plasma profile in homozygous familial hypercholesterolemic patients.
Journal: Transfusion and Apheresis Science - Volume 48, Issue 3, June 2013, Pages 391–396