Functional and phenotypic characterization of CD8+CD28+ and CD28− T cells in atopic individuals sensitized to Dermatophagoides pteronyssinus

Our data confirm phenotypic and functional differences between CD28+ and CD28− T cells, irrespective of atopic status. Purified human CD8+CD28− T cells, freshly isolated from peripheral blood, do not have suppressor properties on allergen- specific proliferation or on cytokine synthesis in PBMC.