Metabolic adaptation of tissues to stress releases metabolites influencing innate immunity

• Tissue adaptation to stress impose metabolic rewiring.
• Variations in metabolite levels leave a signature in stressed tissues.
• Some metabolites connected to energetic pathways behave as second messengers impacting innate immune responses.
• Effector immunocytes rewire their metabolism to be operational in tissues.

Recent developments have demonstrated that metabolic rewiring imposed by adaptation of tissues to stress leads to the release of various metabolites which directly or indirectly impact innate immune responses and inflammation. Some metabolites can behave as second messengers and leave local cues in tissues. Immune cells which infiltrate stressed tissues reorient their metabolism to cope with these microenvironmental cues while preserving their effector functions in tissues.

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