Impact of new sequencing technologies on studies of the human B cell repertoire

• New technologies now allow determination of millions/billions of antibody sequences.
• An unexpectedly high number of somatic variants for each B cell clone is sustained.
• The size of total expressed antibody repertoires is much smaller than anticipated.
• Shared features of repertoires between individuals suggest high level regulation.
• Emerging proteomics and computational methods complement DNA sequencing.

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