کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3345951 1215756 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antigen presentation by Langerhans cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Antigen presentation by Langerhans cells
چکیده انگلیسی

Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.


► CD103+ dDC, not LC are responsible for cross-priming.
► LC promote Th17 in response to extracellular pathogens.
► LC promote Th2 in response to epicutaneous immunization.
► Presentation by LC may result in T cell anergy/deletion.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 25, Issue 1, February 2013, Pages 115–119
نویسندگان
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