کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3345951 | 1215756 | 2013 | 5 صفحه PDF | دانلود رایگان |

Langerhans cells and other skin-resident dendritic cells (DC) are required for the development of cutaneous adaptive immune responses. In vivo experiments using mice with selective DC-subset deficiencies and ex vivo experiments using isolated DC suggests that each subset makes a unique contribution to the adaptive response. This review focuses on the functional outcome of antigen presentation by Langerhans cells. Special attention is given to their ability to promote CD4 T cell differentiation in a variety of inflammatory contexts and whether this subset has the capacity to cross-prime CD8 T cells.
► CD103+ dDC, not LC are responsible for cross-priming.
► LC promote Th17 in response to extracellular pathogens.
► LC promote Th2 in response to epicutaneous immunization.
► Presentation by LC may result in T cell anergy/deletion.
Journal: Current Opinion in Immunology - Volume 25, Issue 1, February 2013, Pages 115–119