کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3346055 | 1215766 | 2011 | 6 صفحه PDF | دانلود رایگان |

Myeloid derived suppressor cells (MDSC) are a heterogeneous population of hematopoietic derived cell precursors that can suppress immune responses in a variety of inflammatory settings. Here we review recent studies detailing expansion of phenotypically and functionally disparate MDSC. Findings related to MDSC accumulation, activation, and mechanisms utilized in immune suppression are presented. Further, we discuss recent reports that suggest MDSC are expanded during transplantation and that modulation of MDSC can participate in preventing graft rejection.
► We detail functional and phenotypic definitions of myeloid derived suppressor cells.
► We review recent data on MDSC activity in transplantation.
► We discuss potential relevance for MDSC in transplantation immunosuppression.
Journal: Current Opinion in Immunology - Volume 23, Issue 5, October 2011, Pages 692–697