کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3346122 1215769 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Aging of hematopoietic stem cells: Intrinsic changes or micro-environmental effects?
چکیده انگلیسی

During development hematopoietic stem cells (HSCs) expand in number and persist throughout life by undergoing self-renewing divisions. Nevertheless, the hematopoietic system does not escape the negative effects of aging, suggesting that self-renewal is not complete. A fundamental issue in stem cell biology relates to such age-dependent loss of stem cell activity. Both stem cell intrinsic factors and extrinsic factors associated with an aging micro-environment could contribute to aging of the hematopoietic system. Recently, changes in the clonal composition of the HSC compartment during aging have been put forward as a key factor. Here, we discuss these recent developments and speculate how they may be of clinical relevance.


► Although highly self-renewing, the hematopoietic system is affected by aging.
► Aging effects include intrinsic as well as micro-environmental (extrinsic) effects.
► Data on the effects of aging on human HSCs are still rare.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 23, Issue 4, August 2011, Pages 512–517
نویسندگان
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