کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3346126 | 1215769 | 2011 | 6 صفحه PDF | دانلود رایگان |

Immune function declines progressively with age, resulting in increased susceptibility of the elderly to infection and impaired responses to vaccines. A diverse repertoire of T cells is essential for a vigorous immune response, and an important manifestation of immune aging is the progressive loss of repertoire diversity, predominantly among CD8 T cells in both mice and humans. Importantly, perturbations in the peripheral T cell repertoire, including reduction of the CD4:CD8 ratio and cytomegalovirus-driven T cell clonal expansions, make a major contribution to the ‘immune risk phenotype’ defined for humans, which predicts two-year mortality in very old individuals.
► Repertoire diversity declines with age.
► Clonally expanded T cells develop in the memory pool with age.
► Reduced repertoire diversity leads to impaired immunity.
► Fortuitously cross-reactive memory cells may recognize new antigens.
► Persistent CMV infection strongly correlates with the immune risk phenotype.
Journal: Current Opinion in Immunology - Volume 23, Issue 4, August 2011, Pages 537–542