کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3346126 1215769 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The narrowing of the CD8 T cell repertoire in old age
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
The narrowing of the CD8 T cell repertoire in old age
چکیده انگلیسی

Immune function declines progressively with age, resulting in increased susceptibility of the elderly to infection and impaired responses to vaccines. A diverse repertoire of T cells is essential for a vigorous immune response, and an important manifestation of immune aging is the progressive loss of repertoire diversity, predominantly among CD8 T cells in both mice and humans. Importantly, perturbations in the peripheral T cell repertoire, including reduction of the CD4:CD8 ratio and cytomegalovirus-driven T cell clonal expansions, make a major contribution to the ‘immune risk phenotype’ defined for humans, which predicts two-year mortality in very old individuals.


► Repertoire diversity declines with age.
► Clonally expanded T cells develop in the memory pool with age.
► Reduced repertoire diversity leads to impaired immunity.
► Fortuitously cross-reactive memory cells may recognize new antigens.
► Persistent CMV infection strongly correlates with the immune risk phenotype.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 23, Issue 4, August 2011, Pages 537–542
نویسندگان
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