کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3346284 | 1591316 | 2008 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokines that regulate autoimmunity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Recent advances have revealed new insights in cytokine regulation of inflammatory responses. TGFβ acting together with pro-inflammatory cytokines such as IL-6 promotes lineage commitment of RORγ-dependent Th17 cells. IL-23 – a member of the IL-12 family – activates the effector function of Th17 cells to promote skin, lung, and mucosal immunity. However, when dysregulated, these cells are important players in autoimmune inflammation. Unexpectedly, IL-27 – another IL-12 family member – plays an opposing role by inducing IL-10 production as well as downregulating both Th17 and Th1-mediated immune pathologies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 20, Issue 6, December 2008, Pages 663–668
Journal: Current Opinion in Immunology - Volume 20, Issue 6, December 2008, Pages 663–668
نویسندگان
Caroline Diveu, Mandy J McGeachy, Daniel J Cua,