کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3346313 1215780 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human leukocyte antigen antibodies in chronic transplant vasculopathy—mechanisms and pathways
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Human leukocyte antigen antibodies in chronic transplant vasculopathy—mechanisms and pathways
چکیده انگلیسی

Transplant recipients exhibiting posttransplant antibodies are at a higher risk for acute and chronic antibody mediated rejection (AMR). The primary alloantigens recognized by antibodies in recipients with AMR are the highly polymorphic HLA class I and class II molecules expressed on the surface of the endothelial cells (ECs) of the graft. Traditionally, anti-HLA antibodies were thought to mediate graft injury through complement-dependent mechanisms. However, recent studies indicate that antibodies can also contribute to alterations in EC function through complement-independent mechanisms by transducing intracellular signals. Anti-HLA antibodies transduce signals that are both pro-inflammatory and pro-proliferative suggesting mechanistic roles in acute and chronic AMR.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 21, Issue 5, October 2009, Pages 557–562
نویسندگان
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