کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3346397 1215784 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
TLR accessory molecules
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
TLR accessory molecules
چکیده انگلیسی

Accessory molecules are required for microbial recognition by Toll-like receptor (TLR), subsequent signaling, and regulation of ensuing immune responses. Accessory molecules regulate TLRs on the cell surface (MD-2 and RP105), or in the endoplasmic reticulum (ER) (Unc93B, PRAT4A, and gp96). Other types of accessory molecules modulate TLR responses by acting directly on TLR ligands (CD14, CD36, HMGB1, and the antimicrobial peptide LL37). These molecules cooperate with TLR, inducing appropriate defense mechanisms. It is important to understand how TLR signaling is controlled by these accessory molecules. These accessory molecules could be promising targets for therapeutic intervention in infectious disease and immune disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 20, Issue 4, August 2008, Pages 420–425
نویسندگان
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