کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3346547 1215793 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Apoptosis induced by the lymphocyte effector molecule perforin
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Apoptosis induced by the lymphocyte effector molecule perforin
چکیده انگلیسی

Recent progress has been made in discovering structure/function relationships of the cytotoxic lymphocyte pore-forming protein — perforin — and its role in immune regulation. Long recognized as a key component of the granule exocytosis mechanism of lymphocyte-mediated apoptosis and in host defence against a variety of pathogens and tumors, more recent attention has focused upon mutations of the perforin gene in some patients with hemophagocytic lymphohistiocytosis. This clinical picture has prompted further work to uncover the molecular structure of perforin and to define its precise role in immune regulation and immunopathology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 19, Issue 3, June 2007, Pages 339–347
نویسندگان
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