کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3346550 | 1215793 | 2007 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Natural killer cells: from CD3−NKp46+ to post-genomics meta-analyses
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
The original definition of NK cells was based on their ‘natural’ cytolytic response against tumor cells and virus-infected cells in the absence of specific immunization. However, the term ‘natural killer’ reflects neither the education/maturation requirements before NK cells can kill nor the entirety of their biological functions. In light of new functional assays, genetic models and genomics analysis, we propose a more accurate definition of NK cells. This definition includes the phenotypical identification of NK cells as CD3−NKp46+ cells across mammalian species. In general, this attempt to redefine NK cells also highlights the need to update the operational definition of cell types in the post-genomic area.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Immunology - Volume 19, Issue 3, June 2007, Pages 365–372
Journal: Current Opinion in Immunology - Volume 19, Issue 3, June 2007, Pages 365–372
نویسندگان
Thierry Walzer, Sébastien Jaeger, Julie Chaix, Eric Vivier,