کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3352928 | 1216809 | 2015 | 14 صفحه PDF | دانلود رایگان |
• Different mouse strains have diverse predisposition to produce innate IgAs
• Innate IgAs allow a controlled bacterial entrance
• IgA-coated bacteria initiate a positive feedback loop of IgA production
• IgA diversity results in microbiota diversification
SummaryThe interrelationship between IgAs and microbiota diversity is still unclear. Here we show that BALB/c mice had higher abundance and diversity of IgAs than C57BL/6 mice and that this correlated with increased microbiota diversity. We show that polyreactive IgAs mediated the entrance of non-invasive bacteria to Peyer’s patches, independently of CX3CR1+ phagocytes. This allowed the induction of bacteria-specific IgA and the establishment of a positive feedback loop of IgA production. Cohousing of mice or fecal transplantation had little or no influence on IgA production and had only partial impact on microbiota composition. Germ-free BALB/c, but not C57BL/6, mice already had polyreactive IgAs that influenced microbiota diversity and selection after colonization. Together, these data suggest that genetic predisposition to produce polyreactive IgAs has a strong impact on the generation of antigen-specific IgAs and the selection and maintenance of microbiota diversity.
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Journal: - Volume 43, Issue 3, 15 September 2015, Pages 527–540