کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3353928 1216898 2009 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Cytokine-Producing Effector B Cells Regulate Type 2 Immunity to H. polygyrus
چکیده انگلیسی

SummaryImmunity to the intestinal parasite Heligomosomoides polygyrus is dependent on the successful generation of T helper 2 (Th2) memory cells. We showed that B cells contribute to immunity against H. polygyrus by producing antibody (Ab) and by promoting expansion and differentiation of primary and memory Th2 cells. We also demonstrated that cytokine-producing effector B cells were essential for effective immunity to H. polygyrus. Tumor necrosis factor alpha production by B cells was necessary for sustained Ab production, whereas interleukin 2 production by B cells was necessary for Th2 cell expansion and differentiation. These results show that B cells mediate protection from pathogens not only by presenting antigen and secreting antibody but also by producing cytokines that regulate the quality and magnitude of humoral and cellular immune responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 30, Issue 3, 20 March 2009, Pages 421–433
نویسندگان
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