کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3354390 | 1216935 | 2006 | 10 صفحه PDF | دانلود رایگان |
SummaryNup98 and Nup96 are components of the nuclear transport machinery and are induced by interferons (IFN). Nup98 is a constituent of an mRNA export pathway that is targeted by viruses and regulated by IFN. However, the role of Nup96 in IFN-related mechanisms has not been established. To investigate the function of Nup96 in vivo, we generated Nup96+/− mice that express low levels of Nup96, as Nup96−/− mice are lethal. The Nup96+/− mice presented selective alterations of the immune system, which resulted in downregulation and impaired IFN α- and γ-mediated induction of MHC I and IFNγ induction of MHC II, ICAM-1, and other proteins. Frequency of TCRαβ+ and CD4+ T cells, which depends on MHC function, is reduced in NUP96+/− mice. Upon immunization, Nup96+/− mice showed impaired antigen presentation and T cell proliferation. Nup96+/− cells and mice were highly susceptible to viral infection, demonstrating a role for Nup96 in innate and adaptive immunity.
Journal: - Volume 24, Issue 3, March 2006, Pages 295–304