کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3354393 1216935 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Natural IgE Production in the Absence of MHC Class II Cognate Help
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Natural IgE Production in the Absence of MHC Class II Cognate Help
چکیده انگلیسی

SummaryIgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 24, Issue 3, March 2006, Pages 329–339
نویسندگان
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