کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3355439 | 1591560 | 2014 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment Elevated CD57 and CD95 expressions are associated with lower numbers of CD4+ recent thymic emigrants in HIV-1 infected immune responders following antiretroviral treatment](/preview/png/3355439.png)
• HIV-1 viremia significantly increases Ki-67, CD57, and CD95 expressions in CD4+ CD31+ naïve T cells.
• 37.5% of IR fail to restored the numbers of CD4+ CD31+ naïve T cells.
• CD57 and CD95 expressions are significantly associated with reconstitution failure of CD4+ CD31+ naïve T cells in IR.
The goal of this study was to understand how immune reconstitution through ART in HIV-1 infected patients affects CD4+ recent thymic emigrants (identified as CD31+ naïve T cells). We performed FACS analysis of CD4+ CD31+ naïve T cells from PBMCs in a cross-sectional age-matched cohort, including 25 healthy controls (HC), 18 untreated HIV-1 infected viremic progressors (VP), 10 untreated HIV-1 infected viral controllers (VC), and 24 HIV-1 infected immune responders (IR) following ART. Our data reveal that 37.5% of IR failed to restore their CD4+ CD31+ naïve T cell counts. In addition, significantly higher expressions of Ki67, CD57, and CD95 were observed in CD4+ CD31+ naïve T cells of both VP and IR comparing to HC and VC. The significantly elevated CD57 and CD95 expressions are observed in IR with low CD4+ CD31+ naïve T cell counts. Therefore, our data indicate an incomplete immune reconstitution of CD4+ CD31+ naïve T cells in more than one third of IR, which is associated with HIV-1 driven immunological phenotypic alterations.
Journal: Immunology Letters - Volume 158, Issues 1–2, March–April 2014, Pages 1–6