Depletion of IL-22 during culture enhanced antigen-driven IFN-γ production by CD4+T cells from patients with active TB

► IFN-γ and IL-22 produced by distinct CD4+T cell subsets. ► The response of IFN-γ and IL-22 were regulated by different signaling molecules. ► Reciprocal relationship between IFN-γ and IL-22 production in human TB disease. ► IL-22 affected the phenotype of IFN-γ+CD4+T cells.