کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3355701 1591576 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Triggering of toll-like receptor signaling pathways in T cells contributes to the anti-tumor efficacy of T cell responses
چکیده انگلیسی

Traditionally, expression of toll-like receptors (TLRs) has been associated with innate immune cells in particular professional antigen presenting cells and natural killer cells. This led to the concept that the adjuvant effects of ligation of TLR in a host occur mainly in innate immune cells. However, this concept has been challenged by recent studies including ours demonstrating that T cells express appreciated levels of different TLRs, which can serve as costimulatory co-receptors during polyclonal and antigen-specific stimulation of T cells. Because T cells express low levels of TLRs as compared to innate immune cells, increasing the expression levels of TLRs in T cells can significantly maximize their responses to the costimulatory effects of TLR ligation. This review article focuses on the potential role of TLR expression in T cells in their responses to vaccination regimen containing TLR agonists and how it can be modulated to optimize anti-tumor immunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 137, Issues 1–2, 30 June 2011, Pages 9–14
نویسندگان
,