کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3355941 1217224 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
چکیده انگلیسی

Thymosin beta 4 (Tβ4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, Tβ4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic Tβ4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that Tβ4 is a key activator of NK cell cytotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 123, Issue 1, 24 March 2009, Pages 72–76
نویسندگان
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