کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3356060 1217234 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IDO: A double-edged sword for TH1/TH2 regulation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
IDO: A double-edged sword for TH1/TH2 regulation
چکیده انگلیسی

Indoleamine 2,3-dioxygenase (IDO) has been well defined as one of the important immunosuppressive properties for TH1 cell-mediated immune responses, but its function in TH2 dominant system is poorly understood. Recently, an appreciable number of publications suggest that the role of IDO in TH2 cell regulation may be different from that of TH1 immune responses. Here we review the evidence on the regulatory function of IDO and tryptophan metabolites in TH1/TH2 differentiation. We propose that IDO-kynurenine pathway can serve as a negative feedback loop for TH1 cells but it may play a distinct role in up-regulating TH2 dominant immune responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 121, Issue 1, 16 November 2008, Pages 1–6
نویسندگان
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