کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3356144 1217238 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recognition of acetylated oligosaccharides by human L-ficolin
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Recognition of acetylated oligosaccharides by human L-ficolin
چکیده انگلیسی
The complement system is a protein cascade capable of neutralizing invading pathogens. One of its activation pathways is the lectin pathway which is dependent on the binding of MBL or the ficolins. The specificity of L-ficolin binding has been investigated previously and it was observed that binding is dependent on acetyl groups. If this was the only requirement this would enable L-ficolin to bind to most mammalian glycosylations since they contain acetylated monosaccharides. To investigate this further L-ficolin was subjected to glycan-array analysis in which L-ficolin binding to 279 different glycans was investigated. Few of these bound L-ficolin above background level but clear structural requirements were discovered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 118, Issue 2, 30 June 2008, Pages 152-156
نویسندگان
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