کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3356578 1217271 2006 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Co-inhibitory role of T-cell-associated B7-H1 and B7-DC in the T-cell immune response
چکیده انگلیسی

B7-H1 and B7-DC expressed on antigen-presenting cells inhibit the T-cell response via the PD-1 counter–receptor on T cells, and co-stimulate T-cell immunity under certain conditions via an unidentified co-stimulatory receptor. However, little is known about the functional consequence of T-cell-associated B7-H1 or B7-DC in the T-cell immune response. Therefore, we evaluated the physiological role of B7-H1 and B7-DC expressed on T cells in terms of cell proliferation and cytokine production by alloreactive T cells. We found that PD-1, B7-H1, and B7-DC were up-regulated in alloreactive CD4+ and CD8+ T cells in vitro and in vivo. In the alloreactive T–T model, blockade of the B7-H1:PD-1 or B7-DC:PD-1 pathways significantly increased the proliferation, and IFN-γ and IL-2 production of alloreactive T cells, although it did not affect the production of other cytokines, including IL-4, IL-10, and IL-12. The data indicate that T-cell-associated B7-H1 and B7-DC negatively regulate the T-cell response via the T–T interaction.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 102, Issue 2, 15 February 2006, Pages 222–228
نویسندگان
, , , , , , , ,