Linfopoyesis temprana en médula ósea adulta

Development of lymphoid cells from hematopoietic stem cells is an ordered process where multiple alternate lineage potentials are gradually lost and lineage commitment is coincident with gain of specialized functions. Over the last few years remarkable advances have been made in characterizing primitive progenitors that initiate the lymphoid program, and patterns of transcriptional activity controlling lineage fate decisions during normal hematopoiesis, but less is known about environmental signals that may influence the differentiation pathway stability. This review discusses the current knowledge with relevance to hierarchy and early events in lymphopoiesis and their relationship to hematopoietic microenvironment.