کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3367083 | 1218427 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Plasticity of osteoprogenitor cells
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
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چکیده انگلیسی
Plasticity is the ability to give rise to cell types whose phenotype is different from that of the source tissue. Osteoblasts originate in progenitors located in the bone marrow or around blood vessels. Marrow stromal cells can differentiate into adipocytes, in part at the expense of osteoblasts. The osteoblast-adipocyte balance is influenced by systemic factors, chiefly hormones, and local factors in the microenvironment, as well as by mechanical loads, which induce or suppress the activity of transcription factors crucial to the differentiation of each cell type. New insights into the molecular mechanisms involved in controlling the osteoblast-adipocyte balance are unlocking doors to a vast array of innovative treatment strategies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Joint Bone Spine - Volume 74, Issue 6, December 2007, Pages 536-539
Journal: Joint Bone Spine - Volume 74, Issue 6, December 2007, Pages 536-539
نویسندگان
Marie Hélène Lafage-Proust, Thierry Thomas, Alain Guignandon, Luc Malaval, Aline Rattner, Laurence Vico,