کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368172 1218774 2009 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Impact of vitamin D receptor activity on experimental autoimmune prostatitis
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Impact of vitamin D receptor activity on experimental autoimmune prostatitis
چکیده انگلیسی

Chronic non bacterial prostatitis is a chronic inflammatory syndrome. Its etiology and physiopathology are unclear and treatments are empirical and ineffective in most cases. Autoimmunity has been proposed as an etiology. In the present report, we investigated the impact of vitamin D receptor silencing, by use of VDR-KO NOD mice and the immune-modulating effect of the vitamin D3 analog TX527 on the development of Experimental Autoimmune Prostatitis in NOD mice. VDR-KO NOD mice developed a more aggressive form of autoimmune prostatitis characterized by a greater lymphoproliferative response against prostate antigen in vitro (6.92 ± 4.77 vs. 2.47 ± 0.41 21 days after disease induction, p < 0.05) and higher levels of specific INFγ secretion (471 ± 6 vs. 386 ± 5 pg/ml, p < 0.01). This was accompanied in vivo by more severe lesions and augmented mononuclear cell infiltration in the prostate gland. On the other hand, although analog-treated mice showed a significant reduction in the spleen T-cell specific proliferative response against prostate antigen in vitro, no effect on disease development was observed.We conclude that vitamin D receptor modulation holds the promise of interfering with autoimmune prostatitis. Introduction of more powerful analogs, or combinations with anti-T-cell reagents may represent therapeutic solutions for these group of patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 32, Issue 2, March 2009, Pages 140–148
نویسندگان
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