کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3368364 | 1218785 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of Th1 and Th17 cells in organ-specific autoimmunity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Role of Th1 and Th17 cells in organ-specific autoimmunity Role of Th1 and Th17 cells in organ-specific autoimmunity](/preview/png/3368364.png)
چکیده انگلیسی
CD4+ IFN-γ-producing Th1 cells have long been associated with the pathogenesis of many organ-specific autoimmune diseases; however, the observation of disease in mice deficient in molecules involved in Th1 cell differentiation raised the possibility that other effector T cells were responsible for inducing autoimmunity. Recently, a new CD4+ effector T cell subset that produces IL-17 (Th17) has emerged. The fact that Th17 cells are highly auto-pathogenic has fueled a debate as to what role, if any, Th1 cells play in the induction of tissue inflammation and autoimmune disease. This review will discuss the respective roles of the Th1 and Th17 subsets in organ-specific autoimmunity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 31, Issue 3, November 2008, Pages 252–256
Journal: Journal of Autoimmunity - Volume 31, Issue 3, November 2008, Pages 252–256
نویسندگان
Valérie Dardalhon, Thomas Korn, Vijay K. Kuchroo, Ana C. Anderson,