کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3368400 | 1592315 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 30, Issues 1–2, February–March 2008, Pages 63–67
Journal: Journal of Autoimmunity - Volume 30, Issues 1–2, February–March 2008, Pages 63–67
نویسندگان
Aymeric Binard, Laëtitia Le Pottier, Alain Saraux, Valérie Devauchelle-Pensec, Jacques-Olivier Pers, Pierre Youinou,