کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368410 1218788 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Large functional repertoire of regulatory T-cell suppressible autoimmune T cells in scurfy mice
چکیده انگلیسی

Scurfy mice which lacks functional Foxp3 transcription factor and CD4+CD25+Foxp3+ regulatory T (Treg) cells, spontaneously develop autoimmune responses against skin, lung, liver and tail. However, many organs/tissues are spared from autoimmune attack. Here, we demonstrate that scurfy mice contain dormant autoimmune T cells that induced new diseases such as sialoadenitis, dacryoadenitis, pancreatitis, gastritis, intestinal inflammation, colitis, and myositis in RAG-1 KO mice. Inflammation in as many as 12 organs/tissues was consistently induced in individual recipients with scurfy lymph node cells containing as few as 1.25 × 106 CD4+ T cells. Moreover, transfer of the multiple organ autoimmune diseases could be suppressed by as little as 0.5 × 106 CD4+CD25+ Treg cells, mediated by inhibiting autoimmune T-cell expansion. Our study provides evidence for the presence of a large repertoire of autoimmune lymphocytes against various organs/tissues in scurfy mice as well as Treg cells in B6 mice capable of suppressing the expansion of these autoimmune lymphocytes. Various conditions that control the expression of autoimmune T cells are discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 29, Issue 1, August 2007, Pages 10–19
نویسندگان
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