کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368424 1218789 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Properties and function of polyreactive antibodies and polyreactive antigen-binding B cells
چکیده انگلیسی

The advent of hybridoma technology has made it possible to study in-depth individual antibody molecules. These studies have revealed a number of surprises that have and are continuing to change our view of the immune system. None of these was more surprising than the demonstration that many antibody molecules are polyreactive – that is they can bind to a variety of different and structurally unrelated self- and non-self-foreign antigens. These findings make it clear that self-reactivity is a common and not necessarily forbidden or pathogenic feature of the immune system and that the well-known broad antibacterial activity of natural antibodies is largely due to polyreactive antibodies. In this brief review we will discuss these insights and their impact on basic and clinical immunology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 29, Issue 4, December 2007, Pages 219–228
نویسندگان
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