کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3368425 1218789 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Physiopathology of natural auto-antibodies: The case for regulation
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Physiopathology of natural auto-antibodies: The case for regulation
چکیده انگلیسی

The cause of autoimmune diseases remains unknown and, as a consequence, disease prediction and prophylaxis are not part of current clinical practice. Many autoimmune syndromes are accompanied by serological evidence of autoimmunity in the form of circulating auto-antibodies (AAb). As normal individuals produce large amounts of AAb, exploring the main differences between such physiologic AAb and those classified as pathogenic may provide the clues needed for new clinical approaches to this group of disorders. Reviewing the differential characteristics of normal and disease-associated autoantibodies, we conclude that the problem will be best tackled if we understand how the organism normally ensures that autoantigen-driven B cell activation does not lead to high titers of autoantibodies and severe autoimmunity. As natural activation of autoreactive B cells occur by both T cell dependent and T cell independent mechanisms, we argue that absence of clonal expansion in normal autoreactive B cells upon activation does not result from lack of appropriate stimulation but, rather, from the presence of negative regulation and suppressive mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Autoimmunity - Volume 29, Issue 4, December 2007, Pages 229–235
نویسندگان
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