کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3368436 | 1218789 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Toll like receptors and autoimmunity: A critical appraisal Toll like receptors and autoimmunity: A critical appraisal](/preview/png/3368436.png)
There is a constant interplay between the innate and adaptive immune systems, which leads to a protective immune response against pathogens and contributes effectively to self–non-self discrimination. Toll-like receptors (TLRs) are key components of the innate immune system, which activate multiple inflammatory pathways and coordinate systemic defense against pathogens. In addition to recognizing unique molecular patterns associated with different classes of pathogens, TLRs may also recognize a number of self proteins and endogenous nucleic acids. Data originating predominantly from animal models of autoimmune disease and circumstantial data from human patients suggest that inappropriate activation of TLR pathways by endogenous or exogenous ligands may lead to the initiation and/or perpetuation of autoimmune responses and tissue injury.
Journal: Journal of Autoimmunity - Volume 29, Issue 4, December 2007, Pages 310–318